Tibetan plateau with grazing yaks and brown mountains.
Credit: © Belozorova Elena / Fotolia
The Tibetan people have inherited variants of five different genes that help them live at high altitudes, with one gene originating in the extinct human subspecies, the Denisovans. Hao Hu and Chad Huff of the University of Texas, Houston, and colleagues report these findings in a new study published April 27th, 2017 in PLOS Genetics.
The study represents a comprehensive analysis of the demographic history of the Tibetan population and its adaptations to the challenges of living at high altitudes. The results also provide a rich genomic resource of the Tibetan population, which will aid future genetic studies.
Tatum Simonson adds: “The comprehensive analysis of whole-genome sequence data from Tibetans provides valuable insights into the genetic factors underlying this population’s unique history and adaptive physiology at high altitude. This study provides further context for analyses of other permanent high-altitude populations, who exhibit characteristics distinct from Tibetans despite similar chronic stresses, as well as lowland populations, in whom hypoxia-related challenges, such those inherent to cardiopulmonary disease or sleep apnea, elicit a wide-range of unique physiological responses. Future research efforts will focus on identifying the interplay between various adaptive versus non-adaptive genetic pathways and environmental factors (e.g., hypoxia, diet, cold, UV) in these informative populations to reveal the biological underpinnings of individualized physiological responses.”
Hu H, Petousi N, Glusman G, Yu Y, Bohlender R, Tashi T, et al. Evolutionary history of Tibetans inferred from whole-genome sequencing.PLOS Genetics, April 2017 DOI: 10.1371/journal.pgen.1006675