Light-activated control of protein localization in mammalian cells. The protein is initially in the cytoplasm and excluded from the nucleus of the cell (blue area in the middle each cell). Upon illumination, the part of the protein that prevents it from entering the nucleus is cleaved off and the protein is now able to enter

A set of biochemical processes crucial to cellular life on Earth could have originated in chemical reactions taking place on the early Earth four billion years ago, believes a group of scientists from the Francis Crick Institute and the University of Cambridge. The researchers have demonstrated in the lab an enzyme-free metabolic pathway that mirrors

Intact genome from one particular mouse embryonic stem cell. Each of the cell’s 20 chromosomes is colored differently.Credit: University of Cambridge and MRC Laboratory of Molecular Biology Scientists have determined the first 3D structures of intact mammalian genomes from individual cells, showing how the DNA from all the chromosomes intricately folds to fit together inside

This is a 3-D colon cell culture model, as seen from a scanning electron microscope image.Credit:Jennifer Barrila, Biodesign Institute, Arizona State University Vaccines and antimicrobials have done more to transform medicine and extend the average human lifespan than any other scientific breakthrough. Yet infectious diseases remain the world’s no. 1 leading cause of death of

Chromatin immunoprecipitation (ChIP-exo) data obtained in this study, mapping sites of interest. Credit: Didier Trono/EPFL EPFL scientists have carried out a genomic and evolutionary study of a large and enigmatic family of human proteins, to demonstrate that it is responsible for harnessing the millions of transposable elements in the human genome. The work reveals the

Complete capsid of bacteriophage P22 generated with validated atomic models that were derived from the high-resolution cryoEM density map. Credit: C.Hryc and the Chiu Lab Scientists at Baylor College of Medicine, the Lawrence Berkeley National Laboratory, Massachusetts Institute of Technology and Purdue University have completed a model of unprecedented near-atomic resolution of the chemical structure

MIT earth scientists have found evidence that eukaryotes — the domain of life comprising animals, plants, and protists — were present on Earth as early as 2.33 billion years ago, right around the time when oxygen became a permanent fixture in the atmosphere. Credit: Massachusetts Institute of Technology New estimate predates earliest fossil evidence by

Image credit:Flickr/Cosimo Research by the University of Southampton has found that methods used to predict the effect of species extinction on ecosystems could be producing inaccurate results. This is because current thinking assumes that when a species vanishes, its role within an environment is lost too. However, scientists working on a new study have found

This visual abstract depicts the findings of Cortese et al., who show that Zika virus infection in both human hepatoma and neuronal progenitor cells induces drastic structural modification of the cellular architecture. Microtubules and intermediate filaments surround the viral replication factory composed of vesicles corresponding to ER membrane invagination toward the ER lumen. Importantly, alteration

A computer method called ZeitZeiger that uses a sample of blood to accurately predict circadian time – the time of day according to a person’s body clock – is described in new research published in the open access journal Genome Medicine. Dr Jake Hughey, lead author from Vanderbilt University School of Medicine, USA said: “Our

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