NIH funding helps generate private-sector patents


In a study of 365,000 NIH grants — nearly every NIH grant awarded for 27 years — researchers found that 31 percent produce articles that are later cited by patents in the biomedical sector.
Credit: Christine Daniloff/MIT

Research grants issued by the National Institutes of Health (NIH) contribute to a significant number of private-sector patents in biomedicine, according to a new study co-authored by an MIT professor.

Melt ponds provide more light and heat for the ice and the underlying water, but now it turns out that they may also have a more direct and potentially important influence on life in the Arctic waters.

Mats of algae and bacteria can evolve in the melt ponds, which can provide food for marine creatures. This is the conclusion of researchers in the periodical, Polar Biology.

Own little ecosystems

The melt ponds can form their own little ecosystem. When all the sea ice melts during the summer, algae and other organisms from melt ponds are released into the surrounding seawater. Some of this food is immediately ingested by creatures living high up in the water column. Other food sinks to the bottom and gets eaten by seabed dwellers, explains Heidi Louise Sørensen, who is the principal author of the scientific article, continuing:
Given that larger and larger areas of melt ponds are being formed in the Arctic, we can expect the release of more and more food for creatures in the polar sea.
Heidi Louise Sørensen studied the phenomenon in a number of melt ponds in North-Eastern Greenland as part of her PhD thesis at University of Southern Denmark (SDU).

Bo Thamdrup and Ronnie Glud of SDU, and Erik Jeppesen and Søren Rysgaard of Aarhus University also contributed to the work.

Food for seals and sea cucumbers

In the upper part of the water column it is mainly krill and copepods that benefit from the nutrient-rich algae and bacteria from melt ponds. These creatures are eaten by various larger animals, ranging from amphipods to fish, seals and whales. Deeper down, it is seabed dwellers such as sea cucumbers and brittle stars that benefit from the algae that sink down.

For some time now, researchers have been aware that simple biological organisms can evolve in melt ponds — they may even support very diverse communities. But so far it has been unclear why sometimes there are many organisms in the ponds, and on other occasions virtually none.

According to the new study, ‘nutrients’ is the keyword. When nutrients such as phosphorus and nitrogen find their way into a melt pond, entire communities of algae and micro-organisms can flourish.

From the Siberian tundra

Nutrients can find their way into a melt pond in a variety of ways, For example, they can be washed in with waves of sea water; they can be transported by dust storms from the mainland (for example, from the Siberian tundra); or they can be washed with earth from the coast out on the ice, when it rains.

Finally, migratory birds or other larger animals resting on the ice can leave behind sources of nutrient.

Climate change is accompanies by more storms and more precipitation, and we must expect that more nutrients will be released from the surroundings into the melt ponds. These conditions, plus the fact that the distribution of areas of melt ponds is increasing, can contribute to increased productivity in plant and animal life in the Arctic seas, says Professor Ronnie Glud of the Department of Biology at SDU.
Warmer and more windy

There are further factors that may potentially contribute to increased productivity in the Arctic seas:

When the sea ice disappears, light can penetrate down into the water.
water. When it gets warmer on the mainland, this creates more melt water, which can flow out into the sea, carrying nutrients in its wake.
BOX What the researchers did

Six melt ponds in Young Sound in North-Eastern Greenland were selected: two natural and four artificial basins. Phosphorous and nitrogen (nutrients, which are also known from common garden fertilizer) were added in various combinations to four ponds, while two served as control ponds. For a period of up to 13 days Heidi Louise Sørensen measured many different parameters in the melt water, including the content of Chlorophyll a: a pigment that enables algae to absorb energy from light. The chlorophyll content of the phosphorus- and nitrogen-enriched ponds was 2 to 10 times higher than in the control ponds and testifies to an increased content of algae.

BOX This is why the number of melt ponds is on the rise

Global warming is melting more and more sea ice, potentially forming an increasing number of melt ponds. NASA satellites have just measured the smallest ever distribution of sea ice in the Arctic. The melt ponds make the ice darker, so it absorbs, rather than reflects light and thereby it heats. This accelerates the melting process. Satellite photos show that areas with melt ponds are getting bigger each year.

Source: University of Southern Denmark

Heidi Louise Sørensen, Bo Thamdrup, Erik Jeppesen, Søren Rysgaard, Ronnie Nøhr Glud. Nutrient availability limits biological production in Arctic sea ice melt ponds. Polar Biology, 2017; DOI: 10.1007/s00300-017-2082-7

When spring arrives in the Arctic, both snow and sea ice melt, forming melt ponds on the surface of the sea ice. Every year, as global warming increases, there are more and larger melt ponds.

The study, published in the journal Science, examines 27 years of data and finds that 31 percent of NIH grants, which are publicly funded, produce articles that are later cited by patents in the biomedical sector.

“The impact on the private sector is a lot more important in magnitude than what we might have thought before,” says Pierre Azoulay, a professor at the MIT Sloan School of Management, who is one of the authors of the paper.

After reviewing over 365,000 grants — making this a uniquely large study — the research also finds that over 8 percent of NIH grants generate a patent directly.

Intriguingly, the researchers also find no significant difference between “basic” or “applied” research grants in terms of the frequency with which those projects helped generate patents; both kinds of research spill over into productive private-sector uses.

“If you thought the NIH exists in an ivory tower, you’re wrong,” Azoulay says. “They are the nexus of knowledge that really unifies two worlds.”

The paper, “The Applied Value of Public Investments in Biomedical Research,” is co-authored by Azoulay, who is the International Programs Professor of Management at MIT Sloan; Danielle Li PhD ’12, an assistant professor at Harvard Business School; and Bhaven Sampat, an associate professor at Columbia University’s Mailman School of Public Health.

Decades of grants

The NIH, which has its main campus in Bethesda, Maryland, encompasses multiple research institutes and is the world’s biggest source of public funding for biomedical research, dispersing about $32 billion annually in grants.

To conduct the study, the scholars examined 365,380 NIH grants funded between 1980 and 2007 — nearly every NIH grant awarded for decades. Exactly 30,829 were the direct basis for patents; 17,093 of those were so-called “Bayh-Dole” patents issued to universities and hospitals, something federal legislation made possible starting in 1980.

Of the NIH grants, 112,408 were additionally cited in a total of 81,462 private-sector patents.

And as the authors put it in the new paper, even these NIH-backed research projects that are indirectly cited in later patents “demonstrate the additional reach that publicly funded science can have by building a foundation for private-sector R&D.”

Azoulay, an economist who studies the production and dissemination of scientific knowledge, says the bottom-line figures in the study — the 31 percent and 8 percent of NIH grants that contribute to and more directly generate patents — strike him as being significantly large because of the broad scope of research the NIH supports.

“There is a lot of research we wouldn’t necessarily expect to be relied upon in a patent,” Azoulay explains.

He also noted that such research can be characterized as either “basic” or “applied”; the researchers found little difference in the long-term patent-creating productivity of those categories.

For instance, some research projects can be considered more directly “disease-oriented” than others, but even by this yardstick, the frequency of patent generation does not vary greatly. About 35 percent of “disease-oriented” NIH grants led to patents, compared to 30 percent otherwise.

Overall, Azoulay says, the flow of knowledge from NIH research projects to the commercial market seems clear.

“Grants produce papers, and papers are cited by patents used by pharmaceutical firms,” says Azoulay. “It’s hard to think of an innovation [in biomedicine] that doesn’t have a patent.”

Source: Massachusetts Institute of Technology

Danielle Li, Pierre Azoulay, Bhaven N. Sampat. The applied value of public investments in biomedical research. Science, 30 Mar 2017 ; DOI: 10.1126/science.aal0010

Posted in Health & Medicine on April 1, 2017

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